Detalhe da pesquisa
1.
Human Orphan Cytochrome P450 2U1 Catalyzes the ω-Hydroxylation of Leukotriene B4.
Int J Mol Sci
; 23(23)2022 Nov 23.
Artigo
em Inglês
| MEDLINE | ID: mdl-36498943
2.
Monooxygenase- and Dioxygenase-Catalyzed Oxidative Dearomatization of Thiophenes by Sulfoxidation, cis-Dihydroxylation and Epoxidation.
Int J Mol Sci
; 23(2)2022 Jan 14.
Artigo
em Inglês
| MEDLINE | ID: mdl-35055091
3.
Antidepressant efficacy of a selective organic cation transporter blocker in a mouse model of depression.
Mol Psychiatry
; 25(6): 1245-1259, 2020 06.
Artigo
em Inglês
| MEDLINE | ID: mdl-31619760
4.
Comparison of Various Aryl-Dithiolethiones and Aryl-Dithiolones As Hydrogen Sulfide Donors in the Presence of Rat Liver Microsomes.
Drug Metab Dispos
; 48(6): 426-431, 2020 06.
Artigo
em Inglês
| MEDLINE | ID: mdl-32234734
5.
Metabolism of Anethole Dithiolethione by Rat and Human Liver Microsomes: Formation of Various Products Deriving from Its O-Demethylation and S-Oxidation. Involvement of Cytochromes P450 and Flavin Monooxygenases in These Pathways.
Drug Metab Dispos
; 46(10): 1390-1395, 2018 10.
Artigo
em Inglês
| MEDLINE | ID: mdl-30018103
6.
Role of Arginine 117 in Substrate Recognition by Human Cytochrome P450 2J2.
Int J Mol Sci
; 19(7)2018 Jul 16.
Artigo
em Inglês
| MEDLINE | ID: mdl-30012976
7.
Inhibitory Effects of Trapping Agents of Sulfur Drug Reactive Intermediates against Major Human Cytochrome P450 Isoforms.
Int J Mol Sci
; 18(7)2017 Jul 20.
Artigo
em Inglês
| MEDLINE | ID: mdl-28726718
8.
Ferrocenyl Quinone Methide-Thiol Adducts as New Antiproliferative Agents: Synthesis, Metabolic Formation from Ferrociphenols, and Oxidative Transformation.
Angew Chem Int Ed Engl
; 55(35): 10431-4, 2016 08 22.
Artigo
em Inglês
| MEDLINE | ID: mdl-27276169
9.
Bioactivation of clopidogrel and prasugrel: factors determining the stereochemistry of the thiol metabolite double bond.
Chem Res Toxicol
; 28(6): 1338-45, 2015 Jun 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-25970225
10.
Thiolactone sulfoxides as new reactive metabolites acting as bis-electrophiles: implication in clopidogrel and prasugrel bioactivation.
Chem Res Toxicol
; 26(5): 794-802, 2013 May 20.
Artigo
em Inglês
| MEDLINE | ID: mdl-23527615
11.
Cytochromes P450 catalyze both steps of the major pathway of clopidogrel bioactivation, whereas paraoxonase catalyzes the formation of a minor thiol metabolite isomer.
Chem Res Toxicol
; 25(2): 348-56, 2012 Feb 20.
Artigo
em Inglês
| MEDLINE | ID: mdl-22103858
12.
Metabolic activation of prasugrel: nature of the two competitive pathways resulting in the opening of its thiophene ring.
Chem Res Toxicol
; 25(5): 1058-65, 2012 May 21.
Artigo
em Inglês
| MEDLINE | ID: mdl-22482514
13.
Diversity-oriented synthesis and bioactivity evaluation of N-substituted ferrocifen compounds as novel antiproliferative agents against TNBC cancer cells.
Eur J Med Chem
; 234: 114202, 2022 Apr 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-35279607
14.
Sulfenic acids as reactive intermediates in xenobiotic metabolism.
Arch Biochem Biophys
; 507(1): 174-85, 2011 Mar 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-20869346
15.
Evaluation of deuterium labeled and unlabeled bis-methyl glutathione combined with nanoliquid chromatography-mass spectrometry to screen and characterize reactive drug metabolites.
Chem Res Toxicol
; 24(3): 412-7, 2011 Mar 21.
Artigo
em Inglês
| MEDLINE | ID: mdl-21375241
16.
Formation and fate of a sulfenic acid intermediate in the metabolic activation of the antithrombotic prodrug prasugrel.
Chem Res Toxicol
; 23(7): 1268-74, 2010 Jul 19.
Artigo
em Inglês
| MEDLINE | ID: mdl-20557086
17.
Amino Acids Bearing Aromatic or Heteroaromatic Substituents as a New Class of Ligands for the Lysosomal Sialic Acid Transporter Sialin.
J Med Chem
; 63(15): 8231-8249, 2020 08 13.
Artigo
em Inglês
| MEDLINE | ID: mdl-32608236
18.
Dehydrogenation of the indoline-containing drug 4-chloro-N-(2-methyl-1-indolinyl)-3-sulfamoylbenzamide (indapamide) by CYP3A4: correlation with in silico predictions.
Drug Metab Dispos
; 37(3): 672-84, 2009 Mar.
Artigo
em Inglês
| MEDLINE | ID: mdl-19074530
19.
Metabolic oxidative cleavage of thioesters: evidence for the formation of sulfenic acid intermediates in the bioactivation of the antithrombotic prodrugs ticlopidine and clopidogrel.
Chem Res Toxicol
; 22(2): 369-73, 2009 Feb.
Artigo
em Inglês
| MEDLINE | ID: mdl-19170597
20.
A new generation of ferrociphenols leads to a great diversity of reactive metabolites, and exhibits remarkable antiproliferative properties.
Chem Sci
; 9(1): 70-78, 2018 Jan 07.
Artigo
em Inglês
| MEDLINE | ID: mdl-29629075